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Although clinical trials were virtually unheard of in psychiatry for many years, they are now the gold standard for judging whether drugs are safe and useful. But should they be? What is the true status of clinical trials? Even when they ostensibly demonstrate a benefit...
Editeur :
Wiley
Parution :
2010-03-16
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Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in...
Editeur :
Humana
Parution :
2010-03-12
Collection :
Cancer Drug Discovery and Development
ePub
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Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with...
Editeur :
Springer
Parution :
2010-03-11
ePub
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Cancer is fundamentally a disease of abnormal cell proliferation:Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal...
Editeur :
Springer
Parution :
2010-03-10
Collection :
Current Cancer Research
ePub
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BACE inhibitors and their use in the treatment of Alzheimer's DiseaseBACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development ofBACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for...
Editeur :
Wiley
Parution :
2010-03-05
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Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how...
Editeur :
Wiley
Parution :
2010-02-18
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
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Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low...
Editeur :
Wiley
Parution :
2010-02-12
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The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the...
Editeur :
Wiley
Parution :
2010-01-26
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Designed for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical laboratory applications....
Editeur :
Wiley
Parution :
2010-01-22
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Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy...
Editeur :
Wiley-Blackwell
Parution :
2010-01-22
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All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase...
Editeur :
Wiley
Parution :
2010-01-19
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An increasing number of exercise scientists are applying their skills collaboratively (with medics and physiotherapists) to clinical populations and investigating the effects of exercise in relation to wide-ranging clinical, pathophysiological and psycho-social...
Editeur :
Springer
Parution :
2010-01-08
ePub
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Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated...
Editeur :
Wiley
Parution :
2010-01-06
Collection :
Wiley Series in Drug Discovery and Development
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PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is...
Editeur :
Wiley
Parution :
2010-01-05
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"The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to...
Editeur :
Wiley-Blackwell
Parution :
2009-12-17
ePub
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The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of...
Editeur :
Wiley
Parution :
2009-12-09
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The International Conference of Harmonization (ICH) has worked on har- nizing the stability regulations in the US, Europe, and Japan since the early 1990s. Even though the Stability Guidelines Q1A (R2) was issued over a decade ago, issues surrounding this arena continue...
Editeur :
Springer
Parution :
2009-12-04
Collection :
Biotechnology: Pharmaceutical Aspects
ePub
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Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one...
Editeur :
Wiley
Parution :
2009-11-19
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
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By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges...
Editeur :
Wiley-VCH
Parution :
2009-11-18
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Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In...
Editeur :
Springer
Parution :
2009-11-11
Collection :
Biotechnology: Pharmaceutical Aspects
ePub
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