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Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that...
Editeur :
Springer
Parution :
2011-04-30
ePub
|
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction...
Editeur :
Wiley-VCH
Parution :
2011-03-31
Collection :
Methods & Principles in Medicinal Chemistry
PDF, ePub
|
This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately...
Editeur :
Wiley
Parution :
2011-03-29
ePub
|
Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of...
Editeur :
Springer
Parution :
2011-03-23
Collection :
Current Cancer Research
ePub
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By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion...
Editeur :
Wiley-VCH
Parution :
2011-03-16
Collection :
Methods & Principles in Medicinal Chemistry
PDF, ePub
|
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes...
Editeur :
Humana
Parution :
2011-03-03
Collection :
Current Cancer Research
ePub
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A must-have guide for any professional in the drug manufacturing industry The Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA code. Clinical Trials...
Editeur :
Wiley
Parution :
2011-03-01
PDF
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RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers...
Editeur :
Wiley
Parution :
2011-03-01
ePub
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The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an...
Editeur :
Wiley
Parution :
2011-02-25
PDF, ePub
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This book guides the reader through FDA regulation guidelines and outlines a comprehensive strategy for cost reduction in regulatory affairs and compliance.This book explains six strategies to cost-effectively comply with FDA regulations while maintaining product safety...
Editeur :
Wiley
Parution :
2011-02-11
PDF, ePub
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Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery...
Editeur :
Wiley
Parution :
2011-01-31
PDF, ePub
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Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor...
Editeur :
Springer
Parution :
2011-01-25
ePub
|
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational...
Editeur :
Wiley-VCH
Parution :
2011-01-11
Collection :
Methods & Principles in Medicinal Chemistry
PDF, ePub
|
This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of...
Editeur :
Wiley
Parution :
2010-12-28
ePub
|
Bladder cancer is a common cancer of the urinary tract. It is the fourth leading cause of cancer-related death among men and the seventh among women. Clinical management of bladder cancer is challenging because of the heterogeneity among bladder tumors with respect to...
Editeur :
Humana
Parution :
2010-12-16
Collection :
Cancer Drug Discovery and Development
ePub
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G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms inG Protein...
Editeur :
Wiley
Parution :
2010-12-10
PDF, ePub
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Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes...
Editeur :
Springer
Parution :
2010-12-07
ePub
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The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A...
Editeur :
Humana
Parution :
2010-12-01
Collection :
Cancer Drug Discovery and Development
ePub
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Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental...
Editeur :
Springer
Parution :
2010-11-25
ePub
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We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging...
Editeur :
Springer
Parution :
2010-11-23
ePub
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